Thermodynamics, Energy Transfer And Mathematical Relationship For Brain Dynamics Between Alzheimer's, Parkinson's And ALS Diseases In Combination With Therapeutic Effects Of Musical Sound Frequencies Of Nây-I Şerîf, Instrument Of Ney (Ney: Turkish Reed Flute, Nay).
Abstract:
In this study, it has been suggested that the acoustic spectral properties of the ney (a type of flute), its smooth harmonic structure, and its direct relationship with the rhythm of respiration may have a regulatory effect on the autonomic nervous system and brain networks. EEG, HRV, and clinical observations reported in the lit erature have been evaluated in a manner consistent with the developed theoretical model. Consequently, this study positions music therapy not as a causal treatment method, but as a complementary physical interaction that slows the rate of entropy increase, supports phase harmony, and increases system stability in neurode generative diseases. The presented model aims to establish the music-neurology relationship on a scientific and mathematical basis by offering an interdisciplinary framework. This study examines neurodegenerative diseases, primarily Alzheimer's disease, but also Parkinson's and Amyotrophic Lateral Sclerosis (ALS), within the framework of thermodynamics, physics, and systems theory, going beyond classical biomedical approach es. Neurodegenerative processes are interpreted as decreased energy efficiency, increased entropy production, and disruption of phase coherence between neuronal networks. In this context, Alzheimer's disease is modeled as an accelerated loss of order process in an out-of-equilibrium open biological system. The study also inves tigates music therapy, particularly through acoustic stimuli produced by breath-based instruments such as the ney (a type of flute). Music is defined as a low-energy but high-information-density external input that provides a regular time-frequency structure without overloading the system with high energy. This approach is mathe matically grounded using dissipative structure theory, the free energy principle, and oscillator synchronization models. [1-88].
