The Impact of Sequencing Tumor Suppressor p53 Gene, “The Guardian of the Human Genome” on Cancer Chemotherapy
Abstract:
The purpose of this abstract is to study the Normal Function of p53 gene which codes for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from rapidly growing and dividing (proliferating) too fast or in an uncontrolled way. In normal cells, the p53 protein level is low. DNA damage and other stress signals may trigger the increase of p53 proteins, which have three major functions: (a) growth arrest, (b) DNA repair and (c) apoptosis (cell death). The growth arrest stops the progression of cell cycle, preventing replication of damaged DNA. The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. p53 is the most frequently mutated gene in cancers. It is particularly mutated in some of the most aggressive cancers such as small cell lung cancer, squamous cell lung cancer, and triple-negative breast cancer. The loss of the function of p53 is a major driver of cancer development mainly because, in the absence of p53 the “Guardian of the Human Genome,” cells are no longer adequately protected from mutations and genomic aberrations resulting in cancers. The couple with the family history of cancers, can still have a healthy baby if conceived by in vitro fertilization. By comparing with mutated p53 sequence with the sequence data from the 1000-genome project, we can easily identify with precision and accuracy. the specific mutated nucleotide responsible for causing the disease. Once the mutation on the nucleotide in a gene is identified, we can design drugs to shut off that gene. The long-term purpose of this study is to conquer all old age diseases including cancers, Alzheimer and cardiovascular diseases to prolong human life for deep space travel in search of new homes for humanity in the nearest exo-planet. The ultimate aim is to protect, preserve and spread human intelligence in every corner of the Universe.
