The Emerging Significance of Sarcopenic Obesity in Older Adults with Type 2 Diabetes
Abstract:
Communities worldwide are witnessing a rise in type 2 diabetes and obesity in older adults. Both nutritional fac tors and sedentary behavior lead to progressive age-related loss of muscle mass, termed sarcopenia. “Sacropenic Obesity” refers to the coexistence of decreased muscle mass in the setting of a high body mass index. Older persons with type 2 diabetes are particularly prone to adverse sequelae with sarcopenic obesity. Heightened endovascular inflammation and a high level of insulin resistance add to the elevated risk. Both basic and clinical research is nec essary to evaluate the multidirectional impact of insulin, proinflammatory cytokines, muscle function, and vascular complications. For effective breakthroughs, improved daily habits in concert with novel drug interventions to com bat sarcopenia older persons with type 2 diabetes are showing promise. The impact of both obesity and sarcopenia on the health status of patients with type 2 diabetes is an emerging topic of interest. The concept of sarcopenic obesity and the glucometabolic disease conditions are intimately connected with age-related musculoskeletal dys function and provide ripe avenues for future study.
