Abstract: Science Set Journal of Medical and Clinical Case Studies

Abstract:
This is the case of a 59-year-old female treated for osteoporosis and arthritis. On routine examinations since 6 months the patient has persistent hypercalcemia. Further evaluation revealed primary hepatic lymphoma as the source of her hypercalcemia. It is already known that hypercalcemia is a common complication of malignancy as described by Rodríguez-Gutiérrez et al. [1]. Hypercalcemia happens due to osteolytic metastases or secretion of parathyroid hormone related peptide (PTHrP). In both situations, calcitriol is suppressed so that the intestinal absorption, renal reabsorption, and bone resorption of calcium can be decreased. In some instances, hypercalcemia can be mediated by calcitriol. This is more common in sarcoidosis; however, have been such reports even in mycobacterium infections and hematologic malignancies [2]. Calcitriol-mediated hypercalcemia accounts for less than 1% of all malignancy-related hypercalcemia cases and it is usually found in non-Hodgkin’s lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL).