Abstract: Journal of Clinical and Biomedical Advances

Abstract:
Potentiation of drugs is most needed and an emerging science in the pharmaceutical industry, but meager work has been done. At present potentiation is done by additives/ synergistics but disadvantages are many. In this study, packaged paracetamol tablets were subjected to a mid-infrared (mid-IR) irradiation. The mid-IR was applied through a 2-6 µm mid-IR generating atomizer (MIRGA), recently invented by us. These tablets were clinically trialed and compared with non-irradiated control. The mid-IR exposed tablet dose requirement was reduced by 30-40%which results in the reduction of host stress, overdosing, and cost economical. In summary, clinical trial data and instrumentations validate the mid-IR’s favorable effect on paracetamol.