Abstract: American Journal of Clinical Pathology Research

Abstract:
The biochemical markers involving serum calcium, inorganic phosphate, and alkaline phosphatase (ALP), play cru cial roles in maternal and fetal health. This study evaluated the changes in serum calcium, inorganic phosphate, and alkaline phosphatase in different trimesters of gestation compared to non-pregnant controls. We employed a case con trol design in which serum calcium, inorganic phosphate and alkaline phosphate levels in pregnant and non-pregnant women were investigated using o-cresophthalein complexone method, ammonium molybdate method and King and King's method respectively. Data analysis was carried out using SPSS version 25 program using ANOVA and t- tests. The findings indicated significant decrease in serum phosphate (p= 0.038), calcium (p= 0.019) and alkaline phos phatase (p = 0.008) across trimesters. It is therefore, recommended to monitor these parameters closely, especially in regions with low nutrient intake, to prevent deficiency-related complications.