Pancreatic Cancer: Review on Advancements, Precision Therapies, and Beyond
Abstract:
This review article provides a comprehensive analysis of the current state of pancreatic cancer research, with a focus on recent advancements in early detection and treatment strategies. Pancreatic cancer presents unique challenges due to late-stage diagnoses and limited treatment options, making it imperative to thoroughly examine the ongoing efforts aimed at improving outcomes for affected individuals. Early Detection of Pancreatic Cancer: Although there are currently no established screening tests for early detection, several research initiatives are actively working towards identifying biomarkers and refining imaging techniques. This section explores the progress made in these studies and discusses their potential impact on diagnosing pancreatic cancer in its early stages. Pancreatic Cancer Treatment: This section addresses the complexities associated with pancreatic cancer treatment, including the challenges of surgical intervention and the conventional use of chemotherapy and radiation. In addition, it provides insights into the latest therapeutic approaches, such as novel drug combinations, neoadjuvant chemotherapy, cancer treatment vaccines, and the role of biomarker testing in treatment recommendations. Testing Treatments for Early-Stage and Advanced Pancreatic Cancer: This section outlines ongoing clinical trials investigating various early-stage and advanced pancreatic cancer therapies. It explores the potential of new adjuvant chemotherapy drug combinations, neoadjuvant chemotherapy, cancer treatment vaccines, immunotherapy, and targeted therapy. In particular, it examines specific drug targets, such as the experimental drug MRTX1133 for KRAS G12D mutations, and the exploration of Ras-directed therapies. Stroma-Modifying Drugs: A dedicated section discusses the significance of stroma-modifying drugs, specifically focusing on the dense stroma commonly found in pancreatic cancers. These drugs aim to break down or remodel the stroma, thereby improving the efficacy of chemotherapy drugs and overcoming resistance in cancer cells.
