Abstract: World Journal of Applied Mathematics and Statistics

Abstract:
A potentially life-threatening illness, acquired immune deficiency syndrome affects 39 million individuals worldwide each year. Currently, several antiretroviral medications can help control the disease but cannot treat the human immunodeficiency type 1 virus that causes AIDS. In drug design, topological indices are crucial, aided by quantitative structure-property/activity relationship. In this study, the temperature- based topological indices are calculated using the molecular structure and physicochemical characteristics of non-nucleoside reverse transcriptase inhibitors, such as Nevirapine, Delavirdine, Efavirenz, Etravirine, and Rilpivirine, which are antiretroviral medications. We also examine the pertinent temperature-based topological indices, and it is shown that these indices have a strong correlation and can be used to predict the physicochemical characteristics of HIV-1 treatment medications using quantitative structure-property relationship analysis.