Nutritional and Psychological Intervention Improving Survival and Quality of Life in Terminal Cancer Patients with Pre-Cachexia: A Prospective Clinical Study
Abstract:
Background: Cancer-related cachexia syndrome (CRCS) is highly prevalent in terminal cancer patients, characterized by skeletal muscle loss, anorexia, and fatigue, leading to poor prognosis. Once cachexia be comes irreversible, nutritional interventions are often ineffective. This study aims to evaluate the efficacy of early multidisciplinary intervention (nutrition and psychology) in patients with pre-cachexia.
Methods: We conducted a prospective study at Kaohsiung Municipal Ta-Tung Hospital from January to De cember 2022. Stage IV cancer patients with a BMI $le$ 20 were recruited3. The intervention included per sonalized nutritional counseling, dietary supplements, and psychological support. Outcomes were measured by weight changes, survival rates, and patient satisfaction.
Results: A total of 48 patients were enrolled55. Baseline assessment revealed that 72% and 78% of patients had insufficient protein and calorie intake, respectively6. Following intervention, 61.9% of patients achieved weight gain, and 4.76% maintained stable weight. The 1-year survival rate for the intervention group was 63.7%, compared to a historical control of 50.8% (2018-2019 data)88. Patient satisfaction with the nutrition al education was 100%9.
Conclusion: Early identification and multidisciplinary intervention in pre-cachectic terminal cancer patients significantly improved nutritional status and 1-year survival rates.
