Abstract: Journal of Clinical and Biomedical Advances

Abstract:
Dialium guineense is a medicinal plant used in Traditional Medicine for the treatment of different disease conditions, such as diarrhea, severe cough, bronchitis, wound, stomachaches, malaria, jaundice, ulcer and hemorrhoids. The present study investigated the haematotoxicity of ethanol stem bark extract of D. guineense in rats. Thirty-five (35) adult male Wistar rats weighing 160 to 180 g were randomly assigned to seven groups (5 rats per group). Group I served as control, while rats in the other groups received varied doses of extract (200 - 5000 mg/kg body weight, bwt) orally for 28 days. Haematological indices of rat blood were analysed using haematological Swelab auto counter 920E+ (UK) system. The results revealed that graded doses of ethanol extract of D. guineense stem bark did not significantly alter the concentrations of the measured haematological parameters (p > 0.05). These results suggest that ethanol extract of the medicinal plant has no obvious deleterious effect on the haematopoietic system of rats.