Invasive Stratified Mucin-Producing Carcinoma of Cervix: A Case Report
Abstract:
Invasive stratified mucin-producing carcinoma (ISMC) of the cervix is a rare and recently classified subtype of human papillomavirus (HPV)-associated mucinous adenocarcinoma. First described in 2016 and later included in the WHO classification of tumors of the female reproductive system, ISMC is characterized by unique histological and immunohistochemical features and is considered to be potentially more aggressive than other adenocarcinoma subtypes. We report a case of a 51-year-old menopausal woman who presented with unexplained vaginal bleeding. Imaging and biopsy confirmed cervical cancer, and she underwent laparoscopic radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection. Histopathological evaluation revealed ISMC with distinc tive features including papillary and nested patterns, presence of mucin, and a specific immunoprofile. Postoperative radiotherapy and chemotherapy were administered, and no recurrence was observed during a 12-month follow-up. This case highlights the clinical and pathological characteristics of ISMC, its diagnosis, differential considerations, and treatment strategy, emphasizing the importance of recognizing this rare and potentially aggressive cervical carcinoma variant.
