Evaluation of Imaging in Patients with Posterior Uveitis and Comparative Analysis of Fluorescein and Indocyanine Green Angiography with Spectralis® HRA and Optos
Abstract:
Purpose: Imaging patients with posterior uveitis and comparison of Fluorescein and Indocyanine green angiography with Heidelberg Spectralis®, as well as assessment and comparison with Optos.
Methods: This is a single-center, observational case series study of thirty consecutive individuals with posterior uveitis (18 females and 12 males). 50 eyes received ultra-widefield fluorescein angiography using the Optos® panoramic P200Tx imaging system and the Heidelberg Spectralis® HRA+OCT system's noncontact ultra-widefield module. The photos were captured as a single, unguided shot focused on the macula. The overall area as well as the area inside each of the four visible quadrants were computed and compared between the two imaging modalities. Each quadrant per eye was also reviewed by three masked reviewers to determine which modality photographed the retinal vasculature more peripherally.
Results: The majority of patients (60.0%) were male, 60% of the fifty eyes were right, and 40% were left. Both Fluorescein Fundus Angiography (FFA) and Indocyanine Green angiography (ICGA) groups had their Optos and HRA acquisition. With the exception of subretinal fluid separation (p=0.843>0.05), all other factors for FFA are statistically significant. Except for the Stromal granuloma late phase and CNV, there is no statistically significant difference between the other ICGA variables (Stromal granuloma intermediate phase, Atrophy and Scar). As a consequence, there is no statistically significant difference in any of these factors between the Optos and HRA for ICGA groups.
Conclusions: HRA could diagnose uveitis damage in ICGA and FFA with a higher degree of sensitivity than Optos.
