Abstract: American Journal of Clinical Pathology Research

Abstract:
Hepatic fibrosis (HF) is a pathological condition characterized by over-extracellular matrix (ECM) aggregation and angiogenesis, which easily leads to cirrhosis and hepatocellular carcinoma. Currently, there is no specific drug therapy strategy for this pathological change. More and more evidence shows that microRNAs (miRNAs) carried by exosomes are involved in the early fibrosis process of liver by mediating intercellular communication, and they can be used as potential biomarkers and therapeutic targets for early HF. In this review, we discussed the hepatogenic, stem cell line and worm-derived exosomes according to the main types of exosomes, and summarized in detail the biolog ical functions of coated miRNA and their multi-dimensional roles in hepatic stellate cell activation, ECM deposition, inflammatory infiltration and liver fibrosis. This provides a new way to diagnose, improve and even reverse HF with miRNA in clinical practice.