Abstract: Journal of Gynecology Obstetrics and Mother Health

Abstract:
Cobalamin (vitamin B₁₂) plays a fundamental role in DNA synthesis, cellular division, and neurological develop ment. Disorders of cobalamin metabolism are increasingly recognized as contributors to gynecological and obstet ric complications. This review examines the pathophysiological mechanisms, clinical manifestations, diagnostic challenges, and therapeutic implications of cobalamin deficiency in women of reproductive age, during pregnancy, and in the postpartum period. Gynecological manifestations include infertility, menstrual disorders, recurrent preg nancy loss, and cervical dysplasia. Obstetric consequences range from neural tube defects and fetal growth restric tion to preeclampsia and adverse neurodevelopmental outcomes. Early detection and adequate supplementation are essential to improve maternal and fetal outcomes.