Abstract: World Journal of Medicine and Health Care

Abstract:
Phaeohyphomycosis is a fungal infection caused by dematiaceous or melanized fungi. These fungi are dis tinguished by the predominance of melanin in the cell wall, which acts as a virulence factor. They are ubiq uitous in the environment, and it can be transmitted through inhalation. Phaeohyphomycotic processes may be superficial, subcutaneous, or deeply invasive or disseminated. Invasive diseases (including deep local infections, pulmonary infection, cerebral infection, and disseminated disease) are uncommon. Although, they are associated with high mortality, as they can cause severe illness in both immunocompetent and immuno compromised individuals. Diagnosis can be made through mycological, histopathological, or molecular tech niques. Treatment typically involves surgery or systemic antifungal medications. Here, we report two cases of CNS phaeohyphomycosis, both with post-transplant patients on immunosuppressant.