Abstract: Journal of Infectious Diseases and Viruses Research

Abstract:
Tuberculosis (TB), a contagious disease, is the tenth major cause of death worldwide according to world health organization and over 10 million people had been reported with TB, and 1.6 million people had died from TB in 2017 [1]. TB is caused by gram positive bacteria, Mycobacterium tuberculosis that primarily affects the lungs. Healthy individuals get infected with TB if they inhale aerosols sneezed, spit or coughed by an infected TB patient. On invasion, this bacterium is phagocytosed by alveolar macrophages, where they reside without being affected by host immune responses and cause pathogenesis [2]. M. tuberculosis is able to establish an asymptomatic latent infection that can later reactivate to cause active diseases [3-5]. Despite, many worldwide uses of vaccine, antibiotics and ongoing immense researches, still it is a major enigma for clinicians and researchers to combat this disease. Additionally, foremost concern is with poor management, illiteracy, incorrect diagnosis and poor treatment leading to development of multidrug resistant TB (MDRTB), extensively drug resistant TB (XDR-TB) and totally drug resistant TB (TDR-TB).