Bullfrog Oil and its Potential Anti-inflammatory Effects as Neuroprotective Therapy in Sepsis-associated Encephalopathy
Abstract:
Sepsis is a life-threatening multiple organ dysfunction due to secondary infection and systemic inflammatory responses, which evolves to encephalopathy in 8% to 70% of the cases. Sepsis-associated encephalopathy is characterized by a potential inflammation of the nervous system that can result in cognitive damage, short and long term, in surviving individuals. To reduce these effects, scientists investigate the use of natural resources as more biocompatible and lower-cost therapeutic alternatives. Here, we investigated the rationale behind the role of the bullfrog oil (BFO) in neuroinflammation and neuroprotective potential. Results of the analyses of the articles demonstrate the anti-inflammatory aspects of BFO in different tissues. Additionally, the analyses establish microemulsions as a safe delivery system capable of securing medicinal effects and preventing bullfrog oil-induced hepatotoxicity. Considering the importance of inflammation in sepsis-associated encephalopathy and cognitive impairment, BFO emerges an excellent pharmacological tool to decrease inflammation and prevent the post-sepsis cognition impairment. Due to the excellent therapeutic potential of using bullfrog oil on the treatment of sepsis-associated encephalopathy, future studies should further investigate its therapeutic properties.
