Association of Vimentin Expression with Various Histopathological Parameters According to WHO and Anneroth Grade in Oral Squamous Cell Carcinoma
Abstract:
Background: Numerous factors that increase the risk of oral cancer have been linked to its development. Therefore, there is a pressing need to discover new molecular indicators that can predict the behavior of the cancer and potential targets for treatment. Vimentin has shown a strong correlation with the advancement of oral squamous cell carcino ma (OSCC). This study aims to identify dependable histologic prognostic factors and investigate the association in between vimentin expression and these factors according to Anneroth and WHO grade in OSCC.
Objective: Association of vimentin expression with Anneroth and WHO grade of OSSC.
Method: A cross-sectional study was carried out in the Department of Pathology, Shaheed Suhrawardy Medical Col lege and Hospital, Dhaka, Bangladesh from September 2021 to August 2023. A total of 51 histologically diagnosed cases of OSCC were selected for the study. Among these, 25 cases were resected tumor specimens and 26 were oral mucosal biopsy. Paraffin blocks and slides were prepared after grossing. H&E and IHC staining were done and an alyzed accordingly. All cases were categorized into groups according to WHO and Anneroth grading. The statistical analysis was carried out using the SPSS version 26.
Result: In this study, a significant association of high vimentin expression was found with degree of keratinization, nuclear pleomorphism, pattern of invasion, and stage of invasion. which means that there is a significant association of high vimentin expression with worsening of these parameters. On the other hand, no association of vimentin was found with number of mitoses and lymphoplasmacytic responses. Association of WHO histological grade with Vimen tin immunoreactivity was statistically significant. Association between total Anneroth grade and Vimentin immunore activity was statistically significant also.
