Abstract: Journal of Psychiatry and Neurochemistry Research

Abstract:
Objectives: Study was to assess platelet Monoamine Oxidase-B (MAO-B) activity levels and cognitive functions in alcohol-dependent patients and healthy controls. A possible correlation between platelet MAO-B levels and cognitive functions was also explored.

Methods: 22 alcohol-dependent patients and healthy controls were recruited, and platelet MAO-B levels and cognitive functions were assessed by different laboratory and psychological tests respectively.

Results: Findings revealed lower levels of platelet MAO-B levels and poor cognitive functions in alcohol-dependent patients as compared to controls. Platelet MAO-B activity was significantly associated with only visual retention domain of cognitive functions.

Conclusions: Findings revealed low platelet MAO-B levels and poor cognitive performance in alcohol dependents. Thus, more prospective studies can make us more hopeful to use MAO-B levels as a potential biomarker for alcohol consumption, early abstinence or detoxification, and cognitive functions.