An Investigation of the Relationship Between C-reactive Protein /Albumin Ratio and Microvascular Angina
Abstract:
Objective: This study aimed to investigate the correlation between serum C-reactive protein/albumin ratio (CRP/ALB, CAR) and microvascular angina (MVA), and to assess the predictive value of serum CAR in relation to MVA.
Methods: A total of 70 patients diagnosed with MVA,admitted to the Department of Cardiovascular Medicine at the Second Affiliated Hospital of Dalian Medical University between September 2022 and December 2023 were included in the observation group. Additionally,68 patients with normal or minimal (< 50%) stenosis on coronary angiography, negative ECG exercise test and normal coronary blood flow were randomly selected as the control group using a random number table method. Serum CRP, ALB and other relevant indexes were measured in both groups, with CAR calculated. Logistic regression analysis, Pearson correlation analysis, and receiver operating characteristic (ROC) curve analysis were conducted to identify independent risk factors for microvascular angina.
Results: Compared the MVA and control group, there were significant differences in CRP and CAR (P < 0.05). High serum CAR levels (OR=2.122, 95%CI, 0.609, 3.390, P<0.001) and high serum CRP levels (OR=1.057, 95%CI, 0.640, 1.745, P<0.001) were identified as independent risk factors for MVA, with the risk of MVA increasing with higher CAR and CRP levels. The ROC curve analysis revealed an AUC of 0.771 (95%CI: 0.686-0.842), with a serum CAR cut-off value of 12.02 ng/mL for predicting MVA, demonstrating a sensitivity of 68.4% and specificity of 97.1%.
Conclusions: Serum CAR levels serve as an independent risk factor for MVA and offer valuable predictive information for MVA diagnosis. Monitoring serum CAR levels could aid in the early identification of clinical MVA patients.
