Abstract: World Journal of Clinical Dermatology

Abstract:
Darier’s disease, an autosomal-dominant genodermatosis, which is due to loss of function mutations in ATP2A2 gene encoding, sarco/endoplasmic reticulum calcium adenosine triphosphate isoform 2 (SERCA 2) that impair intracellular Ca2+ signaling. This article reports a case of sporadic Darier’s disease which involved the seborrheic regions (scalp, face, neck, axilla, anterior and posterior trunk and groin) and nails. A remarkable improvement was noted on oral isotretinoin, after 6 months on topical retinoid (tretinoin) and sunscreen with minimal progress. She had no family history of Darier’s disease or a similar rash.