Abstract: World Journal of Molecular Medicine

Abstract:
Autoimmune hepatitis (AIH) is an immuno-mediated inflammatory liver disease of unknown etiology, which does not depend on gender, age, ethnicity, characterized by hypergammaglobulinemia and the presence of anti-LKM1 in blood serum [1]. This article demonstrates the clinical observation of the development of AIH in a patient with type I diabetes mellitus (type I DM). At the age of 8, the child had jaundice syndrome against the background of the underlying disease. Biochemical examination revealed hyperbilirubinemia due to indirect fraction, cholestasis syndrome, and immunological activity of anti-LKM1. Subsequently, an increase in the titer of antibodies to LKM1 was noted, and therefore the patient was prescribed immunosuppressive therapy. Against the background of the ongoing treatment, it was possible to reduce immunological activity and achieve remission. Despite the necessary and regular treatment, the girl remains hyperglycemic and has a high level of glycated hemoglobin.