The Use of 10% Ambroxol Cream on Musculoskeletal Pain A Case Series
Abstract:
Multiple drugs have been available in the treatment of pain. However, despite the availability of pain medications in the market, half of the older population who are taking analgesics still report to suffer from debilitating types of pain. This has led medical practitioners to continuously search for more effective and safe adjuvant analgesics to offer to their patients. This case series highlights the promising effect of Ambroxol 10% cream both on Somatic, Neuropathic and Nociplas tic types of Chronic Pain. It also shows the efficacy of the drug on Acute types of pain in origin. The use of the cream can provide not just relief but also improvement of overall patient function. Ambroxol, a mucolytic drug has been used to be re-purposed due to its potential usefulness in the treatment of neu ropathic pain with blockage of voltage gated sodium channels particularly Nav1..7 and TTx-r 1.8 (Neuropathic and Inflammatory pain.) It has a complex mode of action through its antioxidant & anti-inflammatory properties which may be attributed to its effects in edematous and hyperemic tissues. All patients in the case series showed immediate decrease in pain within 5 to 15 minutes from the time the cream (10% Ambroxol) was applied. 16 out of 23 patients are also taking co-analgesics weeks to months prior to the ap plication of the cream. Peak drug effect and maximum pain relief was noted at 120 minutes and lasted a duration of 240-600 minutes, with 1 patient reporting complete resolution with no recurrence of pain. Among the 26 patients, there were no noted side effects upon initial application of the cream. All patients were monitored for a span of 1-2 weeks from the initial time of application and reported varying degree of pain relief One patient reported decreasing length of efficacy after a few days use of the cream.
