Abstract: Journal of Clinical and Biomedical Advances

Abstract:
Background: Motivated by the questions in the neurological mechanisms of post-traumatic stress disorder (PTSD), the review studies into the details of hypothalamic-pituitary-adrenal (HPA) axis. The review is supplementary to the phenomenon that COVID-19 also triggers negative psychological symptoms and suicidality.

Methods: The review takes γ-aminobutyric acid (GABA) beta receptors for conceptual framework in the transdisciplinary literature search.

Results: Evidence suggests, although interdependent, the presynaptic and postsynaptic elements of GABA activities are independent from each other in normative conditions.

Conclusions: I take my series of clinical trials conducted for the past 2 to 3 years for the guidance of case presentation on the interpretations of the information gathered, and there is no obvious evidence that autism spectrum disorder is associated with the GABA irregularities in PTSD and COVID-19 infections. The presynaptic interventions’ slight influence to the metabolites related to GABA synthesis and degradation suggests the interrelations between GABA synapses and immune reflex.