Abstract: Science Set Journal of Medical and Clinical Case Studies

Abstract:
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that presents diagnostic challenges, particularly in patients with overlapping chronic conditions. Presented is the case of a 71-year-old male with severe COPD who initially presented with respiratory distress but was later found to have progressive asymmetric motor weakness, muscle atrophy, and upper motor neuron signs suggestive of ALS. After an abnormal EMG, the clinical picture supported a motor neuron disease diagnosis. The patient elected to forgo further interventions in favor of comfort-focused care, ultimately requiring palliative intubation for symptom relief. He passed away peacefully after an 18-day hospital course and contributed to organ donation through donation after circulatory death (DCD). This case underscores the importance of early recognition of ALS, the role of multidisciplinary care, and the value of shared decision-making in managing terminal neurodegenerative disease.