Isolation of Streptococcus Mobilis from a Japanese Couple with Helicobacter Pylori-Negative Chronic Gastritis, Intestinal Metaplasia, and Reactive Gastropathy
Abstract:
Reactive gastropathy associated with the infection of gastric microbiota has received limitedattention com pared to Helicobacter pylori. We have reported the association between thethree types of classification for reactive gastropathy and unidentified coccoid bacteria. Thisstudy aimed to culture and isolate gastric micro organisms from H. pylori-negative Japanesecouples with dyspeptic symptoms. They were diagnosed with Type III reactive gastropathy,characterized by preneoplastic gastric mucosal changes such as intestinal metaplasia. Two novel bacterial types, Streptococcus mobilis IV and a species closely related to Streptococcusoralis subsp. tigurinus were isolated from gastric biopsy specimens. After administering asequential combination of anti biotics over six weeks, the couple became asymptomatic withno adverse effects. Given the intracellular and intranuclear invasive characteristics of thebacteria S. mobilis, along with its production of DNase, hydrogen sulfide (H2S), and CHOtoxin, it is important to conduct careful and regular surveillance for Type III reactive gastropathy in populations with a high incidence of gastric cancer. This research significantlyenhances our understanding and management of reactive gastropathy.
