Abstract: World Journal of Medicine and Health Care

Abstract:
Introduction: Peptic ulcer is a persistent ailment impacting approximately 10% of the worldwide populace, primarily caused by Helicobacter pylori (H. pylori) infection. This research aims to develop and assess Tinidazole-loaded calcium alginate beads through the emulsion gelation method to improve drug delivery for sustained release in the stomach.

Research Methodology: Tinidazole-loaded calcium alginate beads were prepared using the emulsion gelation technique. These beads underwent thorough evaluation of their physical and chemical properties, as well as drug release behavior under simulated gastric conditions.

Results and Discussion: Tinidazole-loaded beads demonstrated effective gastro-retentive properties, maintaining therapeutic drug levels at the ulcer site with reduced dosing frequency. This delivery system shows potential for improved treatment of peptic ulcers, enhancing patient outcomes and compliance.