Abstract: World Journal of Medicine and Health Care

Abstract:
Background: Hematopoietic stem cell transplantation (HSCT) has transformed the treatment of blood disorders and autoimmune diseases. Umbilical cord blood (UCB) is a valuable source of stem cells but maintaining UCB quality is crucial for optimizing transplant success.

Objective/Rationale: This review systematically examines factors influencing UCB quality, focusing on collection, processing, and storage practices, with strategies to improve cord blood banking protocols.

Methods: We performed a comprehensive search of studies from databases such as PubMed, Scopus, and Web of Science, synthesizing data on key factors affecting UCB quality.

Results: Critical factors include collection methods, phlebotomy expertise, anticoagulants used, and storage conditions. Optimal UCB collection and advanced cryopreservation techniques enhance UCB integrity.

Conclusion: Improved UCB collection, processing, and storage protocols can significantly enhance transplant outcomes, despite some uncontrollable factors.