Abstract: Journal of Medical Images and Medical Education Research

Abstract:
HCC is the most common primary liver malignancy in Mexico. Cirrhosis is the most significant risk factor. PET CT with 2-[18F] Fluorodeoxyglucose (2-[18F] FDG) has limited sensitivity (40-50%) for early-stage detection, prompting the search for alternative radiotracers. PSMA has demonstrated diagnostic potential due to its expression in tumor- associated vasculature. PSMA has been proposed as diagnostically equivalent to 2- [18F] FDG in HCC patients. This study evaluated the diagnostic efficacy of [18F] PSMA-1007 PET-CT versus 2- [18F] FDG in nine patients with HCC confirmed by CT and pathology reports (study No. 2019/0110). Visual analysis determined study posi tivity, SUVmax values, and tumor-to- background ratio (T/N). A chi-square test assessed the association between tumor differentiation and tracer uptake. Results indicate that [18F] PSMA-1007 PET/CT is an effective non-invasive imaging tool for HCC, aiding in histological grading.